1.    An Engineered Human Fc Domain that Behaves like a pH-Toggle Switch for Ultra-Long Circulation Persistence. Nature Communications 2019 Nov 6 10:5031

2.    An Engineered Human Fc variant with Exquisite Selectivity for FcγRIIIaV158 Reveals that Ligation of FcγRIIIa Mediates Potent Antibody Dependent Cellular Phagocytosis with GM-CSF-differentiated Macrophages. Frontiers in Immunology 2019 Mar. 27. 10: 562

3.    IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector function. Nature Immunology 2017 Aug; 18(8): 889-898.

1.    Antibody discovery

(1)  Naïve B-cell repertoire

(2)  Animal immunization

(3)  Synthetic antibody library

2.    Fc engineering to modulate Fc-mediated immune responses

3.    Complement in neurodegeneration