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SNU Dementia Research Center

Research & Members

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Yong Tae Kwon, Ph.D

Professor
  • Department of Biochemistry & Molecular Biology
  • Department of Biomedical Sciences
  • Seoul National University, College of Medicine

Contact information

  • Tel

    +82-2-740-8547 (Office)

    +82-2-3668-7675 (Lab)

  • E-mail

    yok5@snu.ac.kr

  • Home page

    Link

Recent Publication (selected)

1.    The N-degron pathway mediates ER-phagy. Mol. Cell (2019) 75:1058-1072

2.    Regulation of reticulophagy by the N-degron pathway. Autophagy (2019) 16:373-375

3.    ZZ-Dependent regulation of p62/SQSTM1 in autophagy. Nat. Comms. (2019) 9:4373

4.    Mechanistic insight into the regulation of p62/SQSTM1. Autophagy (2019) 15:735-737

5.    N-terminal arginylation generates a bimodal degron that modulates autophagic proteolysis. PNAS (2018) 115:E2716.


Research Interests

1.    The ubiquitin-proteasome system

(1)  Degradation signals for selective proteolysis

(2)  Functions and mechanisms of N-terminal degrons in proteolysis

2.    The autophagy-lysosome systems

(1)  Autophagic proteolysis by the N-degron pathway

(2)  Aggrephagy, organellophagy (ER, peroxisome, endosomes, lipids etc)

(3)  Xenophagy (virus, bacteria etc)

3.    Targeted degradation

(1)  PROTAC (proteolysis-targeting chimera)

(2)  AUTOTAC (autophagy-targeting chimera)

(3)  Proteinopathy (AD, PD, ALS, amyloidosis)