1.    Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts. (2019) Nature Communications, 10:5535

2.    Arylsulfatase A, a genetic modifier of Parkinson’s disease, is an α-synuclein chaperone. (2019) Brain, doi: 10.1093/brain/awz205

3.    LRRK2 kinase regulates a-synuclein propagation via RAB35 phosphorylation. (2018) Nature Communications, 9(1):3465.

1.    Molecular pathogenesis of Pakinson disease and related neurological diseases

(1)  Protein aggregation process

(2)  Protein aggregate trafficking and secretion

(3)  Mechanism of protein aggregate propagation

(4)  Interplay between protein aggregation and neuroinflammation

(5)  Role of microglia in pathogenesis of neurodegenerative diseases

2.    Biomarkers for Pakinson disease:

progression markers and differential diagnosis

3.    Drug development for Parkinson disease

(1)  Passive immunization

(2)  Small molecule inhibitors of aggregate propagation