+82-2-740-8254 (Office)
+82-2-740-8256 (Lab)
minjlee@snu.ac.kr
1.
Negative-Feedback
Coordination between Proteasomal Activity and Autophagic Flux. Autophagy (2019) 15:726-728.
2.
Dual function
of USP14 deubiquitinase in cellular proteasomal activity and autophagic flux. Cell Reports (2018) 24:732-743.
3.
Open-gate
mutants of the mammalian proteasome show enhanced ubiquitin-conjugate
degradation. Nat Commun (2016) 7:10963.
1. Understanding
regulatory mechanisms of the proteasome and its associated proteins
2. Developing
small-molecule modulators of the ubiquitin-proteasome system
3. Applying protein
dynamics knowledge to various human diseases including cancer, metabolic
diseases, and, especially, neurodegenerative diseases
4.
N-end rule pathway and its
implication in various physiological and pathological processes
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