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1. The
N-degron pathway mediates ER-phagy. Mol.
Cell (2019) 75:1058-1072
2. Regulation
of reticulophagy by the N-degron pathway. Autophagy
(2019) 16:373-375
3. ZZ-Dependent
regulation of p62/SQSTM1 in autophagy. Nat.
Comms. (2019) 9:4373
4. Mechanistic
insight into the regulation of p62/SQSTM1. Autophagy
(2019) 15:735-737
5. N-terminal
arginylation generates a bimodal degron that modulates autophagic proteolysis. PNAS (2018) 115:E2716.
1.
The ubiquitin-proteasome system
(1) Degradation signals
for selective proteolysis
(2) Functions and
mechanisms of N-terminal degrons in proteolysis
2.
The autophagy-lysosome systems
(1) Autophagic
proteolysis by the N-degron pathway
(2) Aggrephagy,
organellophagy (ER, peroxisome, endosomes, lipids etc)
(3) Xenophagy (virus,
bacteria etc)
3.
Targeted degradation
(1) PROTAC
(proteolysis-targeting chimera)
(2) AUTOTAC
(autophagy-targeting chimera)
(3) Proteinopathy (AD,
PD, ALS, amyloidosis)
TOP